Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

B Hubbard, A Gomes, H Dai, J Li, A Case, T Considine et al.. Science. 2013.

Published 2026-10-15Sources checked 2026-10-151 sourceEverstack research teamHow we work

In plain language: Identified an allosteric site through which some compounds can activate SIRT1 for certain substrates.
Limits: Mechanism only; some authors had commercial ties.
Source: doi.org/10.1126/science.1231097 · PubMed 23471411 · Free full text

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