Everstack Evidence

Alpha-ketoglutarate (AKG)

One mouse study; no human aging trials.

Published 2026-10-15Sources checked 2026-10-151 sourceEverstack research teamHow we work

Editorial section. Research summaries are not product claims and contain no product links or offers. A summary is never proof that any product works.

The question

Does AKG extend lifespan?

Study design

Mouse study of calcium AKG started in middle age (2020). ^[1]

What they found

AKG extended lifespan modestly and reduced frailty measures in mice, with stronger effects on healthspan than on lifespan. ^[1]

Limitations

Single mouse study. No human outcome data.

What this does not mean

Animal results are hypotheses for people.

Sources

1. Asadi Shahmirzadi A et al. Cell Metab. 2020;32(3):447-456. doi.org/10.1016/j.cmet.2020.08.004

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