Everstack Evidence

NR and NMN: raising NAD+ is not the same as slowing aging

B for raising NAD+ levels (replicated randomized trials). D for functional or long-term outcomes, which are not established.

Published 2026-10-14Sources checked 2026-10-142 sourcesEverstack research teamHow we work

Editorial section. Research summaries are not product claims and contain no product links or offers. A summary is never proof that any product works.

The question

Do NAD+ precursors raise NAD+ in people, and does that change how people function?

Study design

Randomized crossover trial of NR 1,000 mg/day in 24 healthy middle-aged and older adults (2018). NR trial in aged men with skeletal muscle biopsies (2019). ^[1][2]

What they found

NR was well tolerated and raised blood NAD+ levels. Changes in physical function were not significant in these short trials. ^[1][2]

Limitations

Short trials, small samples, surrogate markers. NMN became lawful as a supplement again in September 2025 but remains a New Dietary Ingredient; we only consider suppliers covered by an acknowledged notification.

What this does not mean

Higher NAD+ in blood does not mean slower aging. Anyone who tells you otherwise is ahead of the evidence.

Sources

1. Martens CR et al. Nat Commun. 2018;9:1286. doi.org/10.1038/s41467-018-03421-7
2. Elhassan YS et al. Cell Rep. 2019;28(7):1717-1728. doi.org/10.1016/j.celrep.2019.07.043

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