Research library / Brain health

Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores

O Okereke, C Vyas, D Mischoulon, G Chang, N Cook, A Weinberg et al.. JAMA. 2021.

Published 2026-10-15Sources checked 2026-10-151 sourceEverstack research teamHow we work

In plain language

Omega-3 1 g/day for about 5 years did not prevent depression and was linked to a small increase in risk.

Limits

Older US adults; one dose.

Source

doi.org/10.1001/jama.2021.21187 · PubMed 34932079 · Free full text

Summary written by Everstack from the published abstract. Verified against Crossref on 2026-10-15. The authors do not endorse Everstack.